Publications (2021-2025) – Plateforme des Microscopies

Travaux publiés dans des revues internationales à comité de lecture (période 2016–2020) ayant fait l’objet de prestations de la Plateforme des Microscopies de l’ US61 ASB (Plateforme IBiSA de Microscopie Electronique de l’Université de Tours)

Les noms des membres de la Plateforme sont soulignés.

Equipes de l’université de Tours – Secteur Biologie & Santé
Equipes de l’université de Tours – Secteur Sciences des Matériaux
Equipes nationales
Equipes Européennes
Equipes internationales
Publications de la plateforme en partenariat avec des équipes de recherche ou des industriels

Equipes de l’université de Tours – Secteur Biologie & Santé

UMR INSERM U1100 : Centre d’Etude des Pathologies Respiratoires (CEPR)

SAIDI A, WARTENBERG M, MADINIER JB, ILANGO G, SEREN S, KORKMAZ B, LECAILLE F, AUCAGNE V, LALMANACH G. Monitoring Human Neutrophil Activation by a Proteinase 3 Near-Infrared Fluorescence Substrate-Based Probe. Bioconjug Chem. 2021 ; 8 : 32(8):1782-1790.

CHAZEIRAT T, DENAMUR S, BOJARSKI KK, ANDRAULT PM, SIZARET D, ZHANG F, SAIDI A, TARDIEU M, LINHARDT RJ, LABARTHE F, BRÖMME D, SAMSONOV SA, LALMANACH G, LECAILLE F. The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V. Carbohydr Polym. 2021 ; 253 : 117261.

LENGA MA BONDA W, LAVERGNE M, VASSEUR V, BRISSON L, ROGER S, LEGRAS A, GUILLON A, GUYETANT S, HIEMSTRA PS, SI-TAHAR M, IOCHMANN S, REVERDIAU P. Kallikrein-related peptidase 5 contributes to the remodeling and repair of bronchial epithelium. FASEB J. 2021 ; 35(10) : e21838.

GUILLON A, BREA-DIAKITE D, CEZARD A, WACQUIEZ A, BARANEK T, BOURGEAIS J, PICOU F, VASSEUR V, MEYER L, CHEVALIER C, AUVET A, CARBALLIDO JM, NADAL DESBARATS L, DINGLI F, TURTOI A, LE GOUELLEC A, FAUVELLE F, DONCHET A, CREPIN T, HIEMSTRA PS, PAGET C, LOEW D, HERAULT O, NAFFAKH N, LE GOFFIC R, SI-TAHAR M. Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein. EMBO J. 2022 ; 41(12) : e108306.

UMR INSERM U1253 : Imagerie et Cerveau (iBrain)

LANZNASTER D, BRUNO C, BOURGEAIS J, EMOND P, ZEMMOURA I, LEFEVRE A, REYNIER P, EYMIEUX S, BLANCHARD E, VOURC’H P, ANDRES CR, BAKKOUCHE SE, HERAULT O, FAVARD L, CORCIA P, BLASCO H. Metabolic Profile and Pathological Alterations in the Muscle of Patients with Early-Stage Amyotrophic Lateral Sclerosis Biomedicines. 2022 ; 10(6):1307.

KHANNA RK, BLANCHARD E, PASCO J, DIOT P, ANGOULVANT D. Reform of the first year of medical studies and diversification of student profiles in France: an unmet need ? BMC Med Educ. 2024 ; 24(1) : 581.

ROY M, ALIX C, BURLAUD-GAILLARD J, FOUAN D, RAOUL W, BOUAKAZ A, BLANCHARD E, LECONTE T, VIAUD-MASSUARD M-C, SASAKI N, SERRIERE S, ESCOFFRE J-M. Delivery of Anticancer Drugs Using Microbubble-Assisted Ultrasound in a 3D Spheroid Model. Mol Pharm. 2024 ; 21(2) : 831-844.

CHEN J, ESCOFFRE JM, ROMITO O, IAZOURENE T, PRESSET A, ROY M, POTIER CARTEREAU M, VANDIER C, WANG Y, WANG G, HUANG P, BOUAKAZ A. Enhanced macromolecular substance extravasation through the blood-brain barrier via acoustic bubble-cell interactions. Ultrason Sonochem. 2024 ; 103:106768.

CORDOVADO A, HERENGER Y, CORMIER C, LOPEZ-MARTIN E, STAMBERGER H, FAIVRE L, DENOMME-PICHON AS, VITOBELLO A, ABDALLAH HH, BARCIA G, COURTIN T, MARTINEZ-DELGADO B, BERMEJO-SANCHEZ E, BARRERO MJ, GASSER B, BEZIEAU S, KÜRY S, WECKHUYSEN S, LAUMONNIER F, TOUTAIN A, VUILLAUME ML. Heterozygous Missense Variants in the ATPase Phospholipid Transporting 9A Gene, ATP9A, Alter Dendritic Spine Maturation and Cause Dominantly Inherited Nonsyndromic Intellectual Disability Hum Mutat. 2025 Mar 5;2025:7085599.

UMR INSERM U1069 : Niche, Nutrition, Cancer & Métabolisme Oxydatif (N2COX)

DOLLY A, LECOMTE T, TABCHOURI N, CAULET M, MICHOT N, ANON B, CHAUTARD R, DESVIGNES Y, OUAISSI M, FROMONT-HANKARD G, DUMAS JF, SERVAIS S. Pectoralis major muscle atrophy is associated with mitochondrial energy wasting in cachectic patients with gastrointestinal cancer. J Cachexia Sarcopenia Muscle. 2022 ; 13(3) : 1837-1849.

ROMITO O, LEMETTRE A, CHANTOME A, CHAMPION O, COUTY N, OULDAMER L, HEMPEL N, TREBAK M, GOUPILLE C, POTIER-CARTEREAU M. Plasma membrane SK2 channel activity regulates migration and chemosensitivity of high-grade serous ovarian cancer cells. Mol Oncol. 2024 ; 18(8) : 1853-1865.

ROBERT A, CROTTES D, BOURGEAIS J, GUEGUEN N, CHEVROLLIER A, DUMAS JF, SERVAIS S, DOMINGO I, CHADET S, SOBILO J, HERAULT O, LECOMTE T, VANDIER C, RAOUL W, GUEGUINOU M. MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development. PLoS Biol. 2024 ; 28 : 22(10).

UMR INSERM U1259 : Morphogénèse et Antigénicité du VIH et du Virus des Hépatites et émergents (MAVIVHe)

EYMIEUX S, ROUILLE Y, TERRIER O, SERON K, BLANCHARD E, ROSA-CALATRAVA M, DUBUISSON J, BELOUZARD S, ROINGEARD P. Ultrastructural modifications induced by SARS-CoV-2 in Vero cells: a kinetic analysis of viral factory formation, viral particle morphogenesis and virion release. Cell Mol Life Sci. 2021 ; 15 : 1-12.

EYMIEUX S, BLANCHARD E, UZBEKOV R, HOURIOUX C, ROINGEARD P. Annulate lamellae and intracellular pathogens Cell Microbiol. 2021 ; 19 : e13328.

EYMIEUX S, UZBEKOV R, ROUILLE Y, BLANCHARD E, HOURIOUX C, DUBUISSON J, BELOUZARD S, ROINGEARD P. Secretory Vesicles Are the Principal Means of SARS-CoV-2 Egress. Cells 2021 ; 10(8) : 2047.

GOMEZ-ESCOBAR E, BURLAUD-GAILLARD J, VISDELOUP C, RIBEIRO E SILVA A, COUTANT C, ROINGEARD P, BEAUMONT E. Incorporation of apolipropotein E into HBV-HCV suviral envelope particles to improve the hepatitis vaccine strategy. Sci Rep. 2021 ; 11 : 21856.

COCHARD J, BULL-MAURER A, TAUBER C, BURLAUD-GAILLARD J, MAZURIER F, MEUNIER JC, ROINGEARD P, CHOUTEAU P. Differentiated Cells in Prolonged Hypoxia Produce Highly Infectious Native-Like Hepatitis C Virus Particles. Hepatology. 2021 ; 74(2) : 627-640.

DURAND S, SEIGNEURET F, BURLAUD-GAILLARD J, LEMOINE R, TASSI MF, MOREAU A, MOUGEL M, ROINGEARD P, TAUBER C, DE ROCQUIGNY H. Quantitative analysis of the formation of nucleoprotein complexes between HIV-1 Gag protein and genomic RNA using transmission electron microscopy. J Biol Chem. 2022 ; 298(1) : 101500.

ROINGEARD P, EYMIEUX S, BURLAUD-GAILLARD J, HOURIOUX C, PATIENT R, BLANCHARD E. The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses. Cell Mol Life Sci. 2022 ; 79(8) : 425.

TREGUIER Y, COCHARD J, BURLAUD-GAILLARD J, LEMOINE R, CHOUTEAU P, ROINGEARD P, MEUNIER JC, MAQUART M. The envelope protein of Zika virus interacts with apolipoprotein E early in the infectious cycle and this interaction is conserved on the secreted viral particles. Virol J. 2022 ; 19(1) : 124.

EYMIEUX S, HOURIOUX C, MARLET J, MOREAU A, PATIENT R, D’ALTEROCHE L, GAUDY-GRAFFIN C, BLANCHARD E, ROINGEARD P. A morphometric analysis of hepatitis B subviral particles shows no correlation of filament proportion and length with clinical stage and genotype. Viral Hepat. 2022 ; 29(9) : 719-726.

AY S, BURLAUD-GAILLARD J, GAZI A, TATIROVSKY Y, CUCHE C, DIANA JS, SCOCA V, DI SANTO JP, ROINGEARD P, MAMMANO F, Di Nunzio F. In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription EMBO J. 2025 ; 44(1) : 166-199.

SEIGNEURET F, EYMIEUX S, SARABIA-VEGA V, LEMOINE R, BURLAUD-GAILLARD J, RAYNAL P, HOURIOUX C, SUREAU C, ROINGEARD P, DE ROCQUIGNY H. The HBV large envelope protein initiates virion assembly by recruiting capsids at membrane rich domains related to late endosome Cell Mol Life Sci. 2025 ; 82(1) : 128.

UMR INSERM U1327 : Membrane Signalling and Inflammation in reperfusion injuries (ISCHEMIA)

CHADET S, ALLARD J, BRISSON L, LOPEZ-CHARCAS O, LEMOINE R, HERAUD A, LERONDEL S, GUIBON R, FROMONT G, LE PAPE A, ANGOULVANT D, JIANG LH, MURRELL-LAGNADO R, ROGER S. P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition. Oncogene. 2022 ; 41(21) : 2920-2931.

AL-HAJJ S, LEMOINE R, CHADET S, GOUMARD A, LEGAY L, ROXBURGH E, HERAUD A, DELUCE N, LAMENDOUR L, BURLAUD-GAILLARD J, GATAULT P, BÜCHLER M, ROGER S, HALIMI JM, BARON C. High extracellular sodium chloride concentrations induce resistance to LPS signal in human dendritic cells. Cell Immunol. 2023 ; 384 : 104658.

UMR CNRS 7261 : Institut de Recherche sur la Biologie de l’Insecte (IRBI)

CERQUEIRA DE ARAUJO A, LEOBOLD M, BEZIER A, MUSSET K, UZBEKOV R, VOLKOFF AN, DREZEN JM, HUGUET E, JOSSE T. Conserved Viral Transcription Plays a Key Role in Virus-Like Particle Production of the Parasitoid Wasp Venturia canescens. J Virol. 2022 ; 96(13) : e0052422.

UZBEKOV R, N’GORAN M, GARANINA A, PANCIONE M, CHAIKA S, BRESSAC C. The Centrosomes of Haploid and Diploid Cells Have an Equal Number of Centrioles in the Parasitoid Wasp Anisopteromalus calandrae. Front Biosci. 2024 ; 29(1) : 28.

GUINET B, LEOBOLD M, HERNIOU E, BLOIN P, BURLET N, BREDLAU J, NAVRATIL V, RAVALLEC M, UZBEKOV R, KESTER K, GUNDERSEN RINDAL D, DREZN J.M., VARALDI J, BEZIER A. A novel and diverse family of filamentous DNA viruses associated with parasitic waps. Virus Evolution. 2024 ; 10(1).

MANAS F, PITEROIS H, LABROUSSE C, BEAUGEARD L, UZBEKOV R, BRESSAC C. Gone but not forgotten : dynalics of sperm storage and potential ejaculate digestion in the black soldier fly Hermetia illucens. R Soc Open Sci. 2024 ; 11(10) : 241205.

UMR CNRS INRA 7247 : Physiologie de la Reproduction et des Comportements (PRC)

ALMIÑANA C, RUDOLF VEGAS A, TEKIN M, HASSAN M, UZBEKOV R, FRÖHLICH T, BOLLWEIN H, BAUERSACHS S. Isolation and Characterization of Equine Uterine Extracellular Vesicles: A Comparative Methodological Study. Int J Mol Sci. 2021 ; 22(2) : 979.

CORDEIRO L, RIOU C, UZBEKOV R, GERARD N. Avian sperm increase in vitro the release of exosomes from SST-enriched organoids. Reproduction. 2021 ; 161(4) : 375-384.

UZBEKOVA S, TEIXEIRA-GOMES AP, MARESTAING A, JARRIER-GAILLARD P, PAPILLIER P, SHEDOVA EN, SINGINA GN, UZBEKOV R, LABAS V. Protein Palmitoylation in Bovine Ovarian Follicle. Int J Mol Sci. 2021 ; 22(21) : 11757.

CORDEIRO L, LIN HH, VITORINO CARVALHO A, GRASSEAU I, UZBEKOV R, BLESBOIS E. First insights on seminal extracellular vesicles in chickens of contrasted fertility. Reprod. 2021 ; 161(5) : 489-498.

SINGINA GN, SHEDOVA EN, UZBEKOV RE, UZBEKOVA S. Effect of different concentrations of follicular fluid exosome-like extracellular vesicles on in vitro ovocyte maturation and embryo development in cattle. Reprod Fertil Dev. 2021 ; 34(2) : 305-306,

DE ALCANTARA-NETO AS, CUELLO C, UZBEKOV R, BAUERSACHS S, MERMILLOD P, ALMIÑANA C. Oviductal Extracellular Vesicles Enhance Porcine In Vitro Embryo Development by Modulating the Embryonic Transcriptome. Biomolecules. 2022 ; 12(9) : 1300.

MAUGRION E, SHEDOVA E.N., UZBEKOV R, TEIXEIRA-GOMES A-P, LABAS V, TOMAS D, BANLIAT C, SINGINA G.N., UZBEKOVA S. Extracellular Vesicles Contribute to the Difference in Lipid Composition between Ovarian Follicles of Different Size Revealed by Mass Spectrometry Imaging. Metabolites. 2023 ; 13(9) : 1001.

UZBEKOV R, SINGINA GN, SHEDOVA EN, BANLIAT C, AVIDOR-REISS T, UZBEKOVA S. Centrosome formation in the bovine early embryo. Cells. 2023 ; 12(9) : 1335.

SCHMALTZ L, BARAKAT E, FLEUROT R, UZBEKOV R, REYNAUD K, LAFFONT L, TSIKIS G, MEROUR I, MERMILLOD P , SAINT DIZIER M. Phosphatidylserine on sperm head interact with Annexin A5 on oviduct luminal cilia to form a sperm reservoir in pigs. Eur J Cell Bio. 2025 ; 104(1) : 151471.

UMR INRA 1282 : Infectiologie et Santé Publique (ISP)

HOLBERT S, BARILLEAU E, ROCHE SM, TROTEREAU J, GEORGEAULT S, BURLAUD-GAILLARD J, WIEDEMANN A, MERESSE S, VIRLOGEUX-PAYANT I, VELGE P. Murine AML12 hepatocytes allow Salmonella Typhimurium T3SS1-independent invasion and intracellular fate. Sci Rep. 2021 ; 11(1) : 22803.

BARILLEAU E, VEDRINE M, KOCZERKA M, BURLAUD-GAILLARD J, KEMPF F, GREPINET O, VIRLOGEUX-PAYANT I, VELGE P, WIEDEMANN A. Investigation of the invasion mechanism mediated by the outer membrane protein PagN of Salmonella Typhimurium. BMC Microbiol. 2021 ; 21(1) : 153.

MALLET C, SOUCI L, LEDEVIN M, GEORGEAULT S, LARCHER T, DENESVRE C. Establishment of a culture model for the prolonged maintenance of chicken feather follicles structure in vitro. PLoS One 2022 ; 7 : 17(10).

LACROIX-LAMANDE S, BERNARDI O, PEZIER T, BARILLEAU E, BURLAUD-GAILLARD J, GAGNEUX A, VELGE P, WIEDEMANN A. Differential Salmonella Typhimurium intracellular replication and host cell responses in caecal and ileal organoids derived from chicken. Vet Res. 2023 ; 54(1) : 63.

BATTISTONI A, LANTIER L, DI TOMMASO A, DUCOURNAU C, LAJOIE L, SAMIMI M, COËNON L, RIVIERE C, EPARDAUD M, HERTEREAU L, POUPEE-BEAUGE A, RIEU J, MEVELEC MN, LEE GS, MOIRE N, GERMON S, DIMIER-POISSON I. Nasal administration of recombinant Neospora caninum secreting IL-15/IL-15R_ inhibits metastatic melanoma development in lung. J Immunother Cancer. 2023 ; 11(5) : e006683.

YAN J, RACAUD-SULTAN C, PEZIER T, EDIR A, ROLLAND C, CLAVERIE C, BURLAUD-GAILLARD J, OLIVIER M, VELGE P, LACROIX-LAMANDE S, VERGNOLLE N, WIEDEMANN A. Intestinal organoids to model Salmonella infection and its impact on progenitors. Sci Rep. 2024 ; ;14(1) :15160.

LAKHRIF Z, POUPEE-BEAUGE A, BOURSIN F, DUCOURNAU C, LANTIER L, MOIRE N, CARPENTIER R, ROSSIGNOL C, MAQUART M, JOSPIN F, MERAT L, CAUL-FUTY M, YAZDANPANAH Y, BOUAKANE A, RIOU M, TOUZE A, ELEOUËT JF, RICHARD CA, HELLE F, LE PODER S, KLONJKOWSKI B, MEUNIER N, ZIENTARA S, PAUL S, MEVELEC MN, AUBREY N, EPARDAUD M, DIMIER-POISSON I. I. Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants. NPJ Vaccines 2025 ; 10 : 75.

SOUCI L, CHOLLOT M, COURVOISIER-GUYADER K, LACHNER J, KERVARREC T, PICHON J, BURLAUD-GAILLARD J, LARCHER T, PASDELOUP D, ECKHART L, DENESVRE C. Marek’s disease virus replication in chicken skin reconstructed in vitro: evidence for viral particles in corneocytes. J Gen Virol. 2025 ; 106(7) : 002123.

UMR INRA 83 : Biologie des Oiseaux et Aviculture (BOA)

BREGEON M, TOMAS D, BERNAY B, ZATYLNY-GAUDIN C, GEORGEAULT S, LABAS V, REHAULT-GODBERT S, GUYOT N. Multifaceted roles of the egg perivitelline layer in avian reproduction: Functional insights from the proteomes of chicken egg inner and outer sublayers J Proteomics. 2022 ; 258 : 104489.

HALGRAIN M, GEORGEAULT S, BERNARDET N, HINCKE MT, REHAULT-GODBERT S. Concomitant Morphological Modifications of the Avian Eggshell, Eggshell Membranes and the Chorioallantoic Membrane During Embryonic Development. Front Physiol. 2022 ; 13 : 838013.

EA 2106 : Biomolécules et Biotechnologies Végétales

CARQUEIJEIRO I, KOUDOUNAS K, DUGE DE BERNONVILLE T, SEPULVEDA LJ, MOSQUERA A, BOMZAN DP, OUDIN A, LANOUE A, BESSEAU S, LEMOS CRUZ P, KULAGINA N, STANDER EA, EYMIEUX S, BURLAUD-GAILLARD J, BLANCHARD E, CLASTRE M, ATEHORTUA L, ST-PIERRE B, GIGLIOLI-GUIVARC’H N, PAPON N, NAGEGOWDA DA, O’CONNOR SE, COURDAVAULT V. Alternative splicing creates a pseudo-strictosidine _-d-glucosidase modulating alkaloid synthesis in Catharanthus roseus. Plant Physiol. 2021 ; 185(3) : 836-856.

EA4245 : Transplantation, Immunology & Inflammation (T2I)

UMR CNRS 4301 : Nanomédicaments et nanosondes (NMNS)

DEL GENIO V, FALANGA A, ALLARD-VANNIER E, HERVE-AUBERT K, LEONE M, BELLAVITA R, UZBEKOV R, CHOURPA I, GALDIERO S. Design and Validation of Nanofibers Made of Self-Assembled Peptides to Become Multifunctional Stimuli-Sensitive Nanovectors of Anticancer Drug Doxorubicin Pharmaceutics 2022 ; 14(8) : 1544

VOZGIRDAITE D, HERVE-AUBERT K, UZBEKOV R, CHOURPA I, ALLARD-VANNIER E. Design, optimization, characterization, and in vitro evaluation of metformin-loaded liposomes for triple negative breast cancer treatment. J Liposome Res. 2024 ; 8 : 1-15.

Equipes de l’université de Tours – Secteur Sciences des Matériaux

UMR CNRS 7347 : Groupe de Recherche en Matériaux, microélectronique, Acoustique, Nanotechnologies (GREMAN)

LIU W, ALAM MNA, LIU Y, AGAFONOV VN, QI H, KOYNOV K, DAVYDOV VA, UZBEKOV R, KAISER U, LASSER T, JELEZKO F, ERMAKOVA A, WEIL T. Silicon-Vacancy Nanodiamonds as High Performance Near-Infrared Emitters for Live-Cell Dual-Color Imaging and Thermometry. Nano Lett. 2022 ; 10.1021.

EA 6299 : Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l’Energie (PCM2E)

GOBENA H.T, LAI S.Y, KOPOSOV A.Y, MAEHLEN J.P, GHAMOUSS F, LEMORDANT. Cycling performance of silicon-carbon composite anodes enhanced through phosphate surface treatment. Battery Energy. 2023 ; 20220062

Recherche Clinique – CHRU Tours

EYMIEUX S, MIQUELESTORENA-STANDLEY E, RABOT N, MAISONS V, TOUCHARD G, BLANCHARD E. Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma Clin Kidney J. 2021 ; 15(2) : 351-353.

POTTIER C, EYMIEUX S, BLANCHARD E, ROBERT J, MARUANI A, LEDUCQ S. Loose anagen hair syndrome: take a closer look ! Br J Dermatol. 2022 ; 187(4).

CAILLOT R, EYMIEUX S, BLANCHARD-LAUMONNIER E, MOINEAU AG, LEDUCQ S. Acquired Alopecia in an 86-year-old Woman: A Quiz. Acta Derm Venereol. 2024 ; 30 : 104.

CATANESE S, BURLAUD-GAILLARD J, BLASCO H, BLANCHARD E, PISELLA PJ, KHANNA RK, EYMIEUX S. Rapid identification of extracellular vesicles in basal tears using transmission electron microscopy. J Fr Ophtalmol. 2025 ; 48(4):104446.

GOETZ V, LEFORT B, BARTH M, GUEGUEN N, BRIS C, BLANCHARD E, BENZ-DE BRETAGNE I, BLASCO H, TARDIEU M, LABARTHE F. Pantethine therapy dramatically rescues end-stage failing heart in a patient with deficiency of coenzyme A biosynthesis ESC Heart Fail. 2025 ; 12(4 ) : 3195-3199.

Recherche Clinique – CHU Dijon

CARMIGNAC V, MIGNOT C, BLANCHARD E, KUENTZ P, AUBRIOT-LORTON M-H, PARKER V E.R., SORLIN1 A, FRAITAG S, COURCET J-B, DUFFOURD Y, RODRIGUEZ D , KNOX R G. , POLUBOTHU S, BOLAND A, OLASO R, DELEPINE M, DARMENCY V, RIACHI M, QUELIN C, ROLLIER P, GOUJON L, GROTTO S, CAPRI Y, JACQUEMONT M-L, ODENT S, AMRAM D, CHEVARIN M, VINCENT-DELORME C, CATTEAU B, GUIBAUD L, ARZIMANOGLOU A, KEDDAR M, SARRET C, CALLIER P, BESSIS D, GENEVIEVE D, DELEUZE J-F, THAUVIN C, SEMPLE R K., PHILIPPE C, RIVIERE J-B, KINSLER V A., FAIVRE L, VABRES P. Clinical spectrum of MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities. Genet Med. 2021 ; 10.1038/s41436

Recherche Clinique – CHU Amiens

ZERBIB Y, GUILAIN N, EYMIEUX S, UZBEKOV R, CASTELAIN S, BLANCHARD E, FRANÇOIS C, CHATELAIN D, BRAULT C, MAIZEL J, ROINGEARD P, SLAMA M. Pathology Assessments of Multiple Organs in Fatal COVID-19 in Intensive Care Unit vs. Non-intensive Care Unit Patients. Front Med (Lausanne). 2022 ; 9 : 837258.

Equipes nationales

Recherche Clinique – APHM La Timone – Marseille

BASSET M, KASPI E, DANIEL L, BLANCHARD E, MARTINEZ E, ROLL P, FRANKEL D. Enigma Portal Case: Exceptional Urinary Crystals Cytopathology. 2025 ; doi: 10.1111/cyt.70039.

Institut Pasteur – Paris

STRESSMANN FA, BERNAL-BAYARD J, PEREZ-PASCUAL D, AUDRAIN B, RENDUELES O, BRIOLAT V, BRUCHMANN S, VOLANT S, GHOZLANE A, HÄUSSLER S, DUCHAUD E, LEVRAUD JP, GHIGO JM. Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection. ISME J. 2021 ; 15(3) : 702-719.

CAVAL V, SUSPENE R, KHALFI P, GAILLARD J, CAIGNARD G, VITOUR D, ROINGEARD P, VARTANIAN JP, WAIN-HOBSON S. Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network. J Biol Chem. 2021 ; 297(3) : 101081.

GALLO G, KOTLIK P, ROINGEARD P, MONOT M, CHEVREUX G, ULRICH RG, TORDO N, ERMONVAL M. Diverse susceptibilities and responses of human and rodent cells to orthohantavirus infection reveal different levels of cellular restriction. PLoS Negl Trop Dis. 2022 ; 16(10) : e0010844.

AICHER SM, STREICHER F, CHAZAL M, PLANAS D, LUO D, BUCHRIESER J, NEMCOVA M, SEIDLOVA V, ZUKAL J, SERRA-COBO J, PONTIER D, PAIN B, ZIMMER G, SCHWARTZ O, ROINGEARD P, PIKULA J, DACHEUX L, JOUVENET N. Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells. J Virol. 2022 ; 96(14) : e0060822.

DUFLOO J, PLANCHAIS C, FREMONT S, LORIN V, GUIVEL-BENHASSINE F, STEFIC K, CASARTELLI N, ECHARD A, ROINGEARD P, MOUQUET H, SCHWARTZ O, BRUEL T. Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells. Nat Commun. 2022 ; 13(1) : 630.

LOPES A, VENDRELL-FERNANDEZ S, DESCHAMPS J, GEORGEAULT S, COKELAER T, BRIANDET R, GHIGO J-M. Bile-induced biofilm formation in Bacteroides thetaiotaomicron requires magnesium efflux by an RND pump. MBio. 2024 ;15(5) : e0348823.

AY S, BURLAUD-GAILLARD J, GAZI A, TATIROVSKY Y, CUCHE C, DIANA JS, SCOCA V, DI SANTO JP, ROINGEARD P, MAMMANO F, DI NUNZIO F. In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription. EMBO J. 2024 ; 10.1038/s44318.

VENDRELL-FERNANDEZ S, BEAMUD B, ABOU HAYDAR Y, AM DE SOUSA J, BURLAUD-GAILLARD J, KORNOBIS E, RAYNAL B, VINH J, BIKARD D, GHIGO JM. Incomplete lytic cycle of a widespread Bacteroides bacteriophage leads to the formation of defective viral particles. PLoS Biology 2025 ; 23(3) : e3002787

EA 4294 : Agents Infectieux, Résistance et chimiothérapie (AGIR), Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, Université d’Amiens

BENTZ M, COLLET L, MOREL V, DESCAMPS V, BLANCHARD E, LAMBERT C, DEMEY B, BROCHOT E, HELLE F. The Conserved YPX3L Motif in the BK Polyomavirus VP1 Protein Is Important for Viral Particle Assembly but Not for Its Secretion into Extracellular Vesicles. Viruses. 2024 ; 16(7) : 1124.

ART-ARNm INSERM : Université d’Orléans

WANG P, PERCHE F, MIDOUX P, CABRAL CSD, MALARD V, CORREIA IJ, EI-HAFCI H, PETITE H, LOGEART-AVRAMOGLOU D, PICHON C. In Vivo bone tissue induction by freeze-dried collagen-nanohydroxyapatite matrix loaded with BMP2/NS1 mRNAs lipopolyplexes. J Control Release. 2021 ; 334 : 188-200.

CBM CNRS UPR 4301 : Centre de Biophysique Moléculaire, Université d’Orléans

NGALLE LOTH A , MAROQUENNE M , MEDJMEDJ A , COSTE F, BIZIEN T, PICHON C, LOGEART-AVRAMOGLOU D, PERCHE F. Structural and functional characterization of a histidylated liposome for mRNA delivery. J Control Release. 2025 ; 379 : 164-176.

EA4708 I3MTO : Imagerie Multimodale Multi-échelle et Modélisation du Tissu Osseux et articulaire, Université d’Orléans

BOUDENOT A, PALLU S, UZBEKOV R, DOLLEANS E, TOUMI H, LESPESSAILLES E. Free-fall landing and interval running have different effects on trabecular bone mass and microarchitecture, serum osteocalcin, biomechanical properties, SOST expression and on osteocyte-related characteristics. Appl Physiol Nutr Metab. 2021 ; 46(12) : 1525-1534.

INSERM U944 : Génomes, biologie cellulaire et thérapeutique, Université de Paris Diderot

MEERTENS L, HAFIRASSOU ML, COUDERC T, BONNET-MADIN L, KRIL V, KÜMMERER BM, LABEAU A, BRUGIER A, SIMON-LORIERE E, BURLAUD-GAILLARD J, DOYEN C, PEZZI L, GOUPIL T, RAFASSE S, VIDALAIN PO, LEGOUT AB, GUENEAU L, JUNTAS-MORALES R, YAOU RB, BONNE G, DE LAMBALLERIE X, BENKIRANE M, ROINGEARD P, DELAUGERRE C, LECUIT M, AMARA A. FHL1 is a key player of chikungunya virus tropism and pathogenesis. C R Biol. 2021 ; 343(4) : 79-89

KRIL V, HONS M, AMADORI C, ZIMBERGER C, COUTURE L, BOUERY Y, BURLAUD-GAILLARD J, KARPOV A, PTCHELKINE D, THIENEL AL, KÜMMERER BM, DESFOSSES A, JONES R, ROINGEARD P, MEERTENS L, AMARA A, REGUERA J. Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture. Nat Commun. 2024 ; 16 : 15(1).

INSERM U996 : Inflmmation, Microbiome and Immunosurveillance (IMI), Université de Paris-Saclay

GALLEGO C, JARACZ-ROS A, LAGANA M, MERCIER-NOME F, DOMENICHINI S, FUMAGALLI A, ROINGEARD P, HERFS M, PIDOUX G, BACHELERIE F, SCHLECHT-LOUF G. Reprogramming of connexin landscape fosters fast gap junction intercellular communication in human papillomavirus-infected epithelia. Front Cell Infect Microbiol. 2023 ; 13:1138232.

LAGANA M, MARGOLLES GC, JARACZ-ROS A, MERCIER-NOME F, ROINGEARD P, LAMBERT PF, SCHLECHT-LOUF G, BACHELERIE F. Optimized protocol for 3D epithelial cultures supporting human papillomavirus replication. STAR Protoc. 2024 ; 5(1) : 102828.

INSERM UMR 1176 : Université Paris-Saclay

SOLARZ J, SOUKASEUM C, FREMONT S, EYMIEUX S, NABLI C, REPERANT C, ROSSI E, BORDET JC, DENIS C, MANGIN P, BOULAFTALI Y, PASTERKAMP RJ, RASLOVA H, BARUCH D, ADAM F, ECHARD, KAUSKOT A. F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIb_ interaction in platelets. Nature Communications volume 16, Article number: 7375 (2025)

INSERM UMR 1064 : Centre de recherche en transplantation et immunologie, Université de Nantes

SIKORSKI M, COULON F, PELTIER C, BRAUDEAU C, GARCIA A, GIRAUD M, RENAUDIN K, KANDEL-AZNAR C, NEDELLEC S, HULIN P, BRANCHEREAU J, VEZIERS J, GABORIAUD P, TOUZE A, BURLAUD-GAILLARD J, JOSIEN R, MCILROY D, BRESSOLLETTE-BODIN C, HALARY F. Non-permissive human conventional CD1c+ dendritic cells enable trans-infection of human primary renal tubular epithelial cells and protect BK polyomavirus from neutralization. PLoS Pathog. 2021 ; 17(2) : e1009042.

INSERM UMR 1307 : CRCI2NA, Université de Nantes

HIRIGOYEN U, GUILBAUD C, KREJBICH M, FOUET M, FRESQUET J, ARNAUD B, COM E, PINEAU C, CADIOU G, BURLAUD-GAILLARD J, ERBS P, FRADIN D, LABARRIERE N, FONTENEAU JF, PETITHOMME T, BOISGERAULT N. Oncolytic viruses alter the biogenesis of tumor extracellular vesicles and influence their immunogenicity. Mol Ther Oncol. 2024 ; 26 : 32(4).

BRIOLAY T, FRESQUET J, MEYER D, KERFELEC B, CHAMES P, ISHOW E, BLANQUART C. Specific Targeting of Mesothelin-Expressing Malignant Cells Using Nanobody-Functionalized Magneto-Fluorescent Nanoassemblies. Int J Nanomedicine. 2024 ; 19: 633-650.

INSERM UMR_S1134 : Biologie Intégrée du Globule Rouge (BIGR), Université de Paris Diderot et des Antilles

ROUSSEL C, MOREL A, DUSSIOT M, MARIN M, COLARD M, FRICOT-MONSINJON A, MARTINEZ A, CHAMBRION C, HENRY B, CASIMIR M, VOLLE G, DEPOND M, DOKMAK S, PAYE F, SAUVANET A, LE VAN KIM C, COLIN Y, GEORGEAULT S, ROINGEARD P, SPITALNIK SL, NDOUR PA, HERMINE O, HOD EA, BUFFET PA, AMIREAULT P. Rapid clearance of storage-induced microerythrocytes alters transfusion recovery. Blood. 2021 ; 137(17) : 2285-2298.

MARIN M, PELTIER S, HADJOU Y, GEORGEAULT S, DUSSIOT M, ROUSSEL C, HERMINE O, ROINGEARD P, BUFFET PA, AMIREAULT P. Storage-Induced Micro-Erythrocytes Can Be Quantified and Sorted by Flow Cytometry. Front Physiol. 2022 ; 13 : 838138.

PELTIER S, MARIN M, DZIECIATKOWSKA M, DUSSIOT M, ROY MK, BRUCE J, LEBLANC L, HADJOU Y, GEORGEAULT S, FRICOT A, ROUSSEL C, STEPHENSON D, CASIMIR M, SISSOKO A, PAYE F, DOKMAK S, NDOUR PA, ROINGEARD P, GAUTIER EF, SPITALNIK SL, HERMINE O, BUFFET PA, D’ALESSANDRO A, AMIREAULT P. Proteostasis and metabolic dysfunction in a distinct subset of storage-induced senescent erythrocytes targeted for clearance. BioRxiv. 2024 ; 11 : 612195.

INSERM U1019 – CNRS UMR 9017 : Centre d’Infection et d’Immunité, Université de Lille – CHU Lille – Institut Pasteur de Lille.

BENTALEB C, HERVOUET K, MONTPELLIER C, CAMUZET C, FERRIE M, BURLAUD-GAILLARD J, BRESSANELLI S, METZGER K, WERKMEISTER E, ANKAVAY M, JANAMPA NL, MARLET J, ROUX J, DEFFAUD C, GOFFARD A, ROUILLE Y, DUBUISSON J, ROINGEARD P, ALIOUAT-DENIS CM, COCQUEREL L. The endocytic recycling compartment serves as a viral factory for hepatitis E virus. Cell Mol Life Sci. 2022 ; 79(12) : 615.

DESMARETS L, DANNEELS A, BURLAUD-GAILLARD J, BLANCHARD E, DUBUISSON J, BELOUZARD S. The KxGxYR and DxE motifs in the C-tail of the Middle East respiratory syndrome coronavirus membrane protein are crucial for infectious virus assembly. Cell Mol Life Sci. 2023 ; 80(12) : 353.

UMR CNRS 3569 : Épidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur Université Paris Cité.

ZOLADEK J, BURLAUD-GAILLARD J, CHAZAL M, DESGRAUPES S, JEANNIN P, GESSAIN A, PARDIGON N, HUBERT M, ROINGEARD P, JOUVENET N, AFONSO PV. Human Claudin-Derived Peptides Block the Membrane Fusion Process of Zika Virus and Are Broad Flavivirus Inhibitors. Microbiol Spectr. 2022 ; 10(5) : e0298922.

INSERM U1111 – UMR CNRS 5308 : Centre International de Recherche en Infectiologie (CIRI), Université Claude Bernard Lyon 1.

ZHONG L, SONG Y, MARZIALI F, UZBEKOV R, NGUYEN XN, JOURNO C, ROINGEARD P, CIMARELLI A. A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway. Life Sci Alliance. 2022 Apr 8 ; 5(7):e202101174. doi: 10.26508/lsa.202101174. Print 2022 Jul.

MARZIALI F, SONG Y, NGUYEN XN, BELMUDES L, BURLAUD-GAILLARD J, ROINGEARD P, COUTE Y, CIMARELLI A. A Proteomics-Based Approach Identifies the NEDD4 Adaptor NDFIP2 as an Important Regulator of Ifitm3 Levels. Viruses. 2023 ; 15(10) : 1993.

RITTER M, CANUS L, GAUTAM A, VALLET T, ZHONG L, LALANDE A, BOSON B, GANDHI A, BODOIRAT S, BURLAUD-GAILLARD J, FREITAS N, ROINGEARD P, BARR JN, LOTTEAU V, LEGROS V, MATHIEU C, COSSET FL, DENOLLY S. The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells. Nat. Commun. 2024 ; 15(1) : 4542.

VADON C, NGUYEN XN, SIAHAAN V, SONG Y, KRISHNAN A, HENRIOT V, CHANTHARATH A, BURLAUD-GAILLARD J, ROINGEARD P, JANKE C, ETIENNE L, FIORINI F, MAGIERA MM, CIMARELLI A. Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores toward the nucleus. Proc Natl Acad Sci U S A. 2025 ; 122(41) : e2505128122.

Centre de Recherche de Biologie Cellulaire : Université de Montpellier

PRIGENT C, UZBEKOV R. Duplication and Segregation of Centrosomes during Cell Division. Cells. 2022 ; 11(15) : 2445.

IRIM – UMR CNRS – Montpellier

INAMDAR K, TSAI FC, DIBSY R, DE PORET A, MANZI J, MERIDA P, MULLER R, LAPPALAINEN P, ROINGEARD P, MAK J, BASSEREAU P, FAVARD C, MURIAUX D. Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53. Elife. 2021 ; 10 : e67321,

ARONE C, MARTIAL S, BURLAUD-GAILLARD J, THOULOUZE M-I, ROINGEARD P, DUTARTRE H, MURIAUX D. HTLV-1 biofilm polarization maintained by tetraspanin CD82 is required for efficient viral transmission. mBio. 2023 ; 14(6) : e0132623.

Equipes européennes

Institut de Génétique et de Biologie Moléculaire et Cellulaire – Illkirch-Granffenstaden

BUSSELEZ J, UZBEKOV R, FRANCO B, PANCIONE M. New insights into the centrosome-associated spliceosome components as regulators of ciliogenesis and tissue identity. WIREs RNA. 2023 ; e1776.

Université d’ Albert-Einstein, Allemagne

Université de Naples Federico II, Italie

BUSSELEZ J, UZBEKOV R, FRANCO B, PANCIONE M. New insights into the centrosome-associated spliceosome components as regulators of ciliogenesis and tissue identity. Wiley Interdiscip Rev RNA. 2023 ; 14(4) : e1776.

Instituto de Agrobiotecnología (IDAB). CSIC-Gobierno de Navarra, Avenida Pamplona 123, Mutilva, 31192, Spain

FERNANDEZ-CALVET A, MATILLA-CUENCA L, IZCO M, NAVARRO S, SERRANO M, VENTURA S, BLESA J, HERRAIZ M, ALKORTA-ARANBURU G, GALERA S, RUIZ DE LOS MOZOS I, MANSEGO ML, TOLEDO-ARANA A, ALVAREZ-ERVITI L, VALLE J. Gut microbiota produces biofilm-associated amyloids with potential for neurodegeneration. Nat Commun. 2024 ; 15(1) : 4150.

Equipes internationales

National University of Science and Technology, Moscou

GARANINA A, EFREMOVA M, MACHULKIN A, LYUBIN E., VOROBYEVA N, ZHIRONKINA O, STRELKOVA O, KIREEV I, ALIEVA I, UZBEKOV R, AGAFONOV V, SHCHETININI, FEDYANIN A, EROFEEV A, GORELKIN P, KORCHEV Y, SAVCHENKO A, ABAKUMOV M. Bifunctional magnetite-gold nanoparticles for magneto-mechanical actuation an cancer cell destruction. Magnetochemistry 2022 ; 8 : 185.

Université de Zurich, Suisse

Department of Biological Sciences, University of Toledo, 3050 W. Towerview Blvd., Toledo, OH 43606, USA

AVIDOR-REISS T, ACHINGER L, UZBEKOV R. The Centriole’s Role in Miscarriages. Front Cell Dev Biol. 2022 ; 10 : 864692.

UZBEKOV R., AVIDOR-REISS T. The centrosome : conclusions and perspectives Cells 2022 ; 11 : 3931.

AVIDOR-REISS T, UZBEKOV R. Revisiting the mystery of centrioles at the beginning of mammalian embryogenesis. J Assist Reprod Genet. 2023 ; 15. doi: 10.1007/s10815-023-02927-4

UZBEKOV R, AVIDOR-REISS T. Comment on : ‘The proximal centriole age in spermatozoa is a potential reason for its different fate in the zygote after fertilization. Open Biol. 2024 ; 14(3) : 230458.

Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York City, New York, USA.

MORICONI C, DZIECIATKOWSKA M, ROY M, D’ALESSANDRO A, ROINGEARD P, LEE JY, GIBB DR, TREDICINE M, MCGILL MA, QIU A, LA CARPIA F, FRANCIS RO, HOD EA, THOMAS T, PICARD M, AKPAN IJ, LUCKEY CJ, ZIMRING JC, SPITALNIK SL, HUDSON KE. Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. Br J Haematol. 2022 ;198(3) : 574-586.

Publications de la plateforme en partenariat avec des équipes de recherche ou des industriels

UZBEKOV R, PRIGENT C. A Journey through Time on the Discovery of Cell Cycle Regulation. Cells. 2022 ; 11(4) : 704.

UZBEKOV R, SINGINA GN, SHEDOVA EN, BANLIAT C, AVIDOR-REISS T, UZBEKOVA S. Centrosome Formation in the Bovine Early Embryo. Cells. 2023 ; 12(9):1335.

UZBEKOV R, UZBEKOVA S, SEVERIN F, PRIGENT C, ARLOT-BONNEMAINS Y. Aurora a kinase begins to localize to the centrosome in the S-phase of the cell cycle in the XL2 cell line. Front. Biosci. 2024 ; 29(9) : 317.