Publications :
Equipes de l’Université de Tours
– Secteur Biologie & Santé

UMR INSERM U1069 : Nutrition, Croissance et Cancer (N2C)

GAMBADE A, ZREIKA S, GUEGUINOU M, CHOURPA I, FROMONT G, BOUCHET AM, BURLAUD-GAILLARD J, POTIER-CARTEREAU M, ROGER S, AUCAGNE V, CHEVALIER S, VANDIER C, GOUPILLE C, WEBER G.
Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells.
Oncotarget. 2016 ; 7(17) : 23785-23800.

BON E, DRIFFORT V, GRADEK F, MARTINEZ-CACERES C, ANCHELIN M, PELEGRIN P, CAYUELA ML, MARIONNEAU-LAMBOT S, OULLIER T, GUIBON R, FROMONT G, GUTIERREZ-PAJARES JL, DOMINGO I, PIVER E, MOREAU A, BURLAUD-GAILLARD J, FRANK PG, CHEVALIER S, BESSON P, ROGER S.
SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer.
Nat Commun. 2016 ; 7 : 13648.

UMR INSERM U1100 : Centre d’Etude des Pathologies Respiratoires (CEPR)

DESOUBEAUX G, GAILLARD J, BOREE-MOREAU D, BAILLY E, ANDRES CR, CHANDENIER J.
Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax.
Pathog Glob Health. 2014 ; 108(3) : 158-163.

GUARINO C, LEGOWSKA M, EPINETTE C, KELLENBERGER C, DALLET-CHOISY S, SIENCZYK M, GABANT G, CADENE M, ZOIDAKIS J, VLAHOU A, WYSOCKA M, MARCHAND-ADAM S, JENNE D.E, LESNER ADAM, GAUTHIER F, KORKMAZ B.
New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases.
J Biol Chem. 2014 ; 289(46) : 31777-31791.

KRYZA T, ACHARD C, PARENT C, MARCHAND-ADAM S, GUILLON-MUNOS A, IOCHMANN S, KORKMAZ B, RESPAUD R, COURTY Y, HEUZE-VOURC’H N.
Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway.
FASEB J. 2014 ; 28(2) : 740-751.

HAMON Y, LEGOWSKA M, HERVE V, DALLET-CHOISY S, MARCHAND-ADAM S, VANDERLYNDEN L, DEMONTE M, WILLIAMS R, SCOTT C, SI-TAHAR M.
Neutrophilic cathepsin C is matured by a multistep proteolytic process and secreted by activated cells during inflammatory lung diseases.
J Biol Chem. 2016 ; 291(16) : 8486-8499.

CHEVALEYRE C, RIOU M, BREA D, VANDEBROUCK C, BARC C, PEZANT J, MELO S, OLIVIER M, DELAUNAY R, BOULESTEIX O, BERTHON P, ROSSIGNOL C, BURLAUD-GAILLARD J, BECQ F, GAUTHIER F, SI-TAHAR M, MEURENS F, BERRI M, CABALLERO-POSADAS I, ATTUCCI S.
The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.
PLoS One. 2016 ; 11(12) : e0168577.

KRYZA T, PARENT C, PARDESSUS J, PETIT A, BURLAUD-GAILLARD J, REVERDIAU P, IOCHMANN S, LABAS V, COURTY Y, HEUZE-VOURC’H N.
Human kallikrein-related peptidase 12 stimulates endothelial cell migration by remodeling the fibronectin matrix.
Sci Rep. 2018 ; 8(1): 6331.

GUILLON A, FOUQUENET D, MORELLO E, HENRY C, GEORGEAULT S, SI-TAHAR M, HERVE V.
Treatment of Pseudomonas aeruginosa biofilm present in endotracheal tubes by poly-L-Lysine.
Antimicrob Agents Chemother 2018, in press

UMR INSERM U1253 : Imagerie et Cerveau (iBrain)

ZEMMOURA I, BLANCHARD E, RAYNAL PI, ROUSSELOT-DENIS C, DESTRIEUX C, VELUT S.
How Klingler’s dissection permits exploration of brain structural connectivity? An electron microscopy study of human white matter.
Brain Struct Funct. 2016 ; 221(5) : 2477-2486.

DANGOUMAU A, MAROUILLAT S, GAILLARD J, UZBEKOV R, VEYRAT-DUREBEX C, BLASCO H, ARNOULT C, CORCIA P, ANDRES C, VOURC’H P.
Inhibition of pathogenic mutant SOD1aggregation in cultured motor neuronal cells by prevention of its SUMOylation on lysine 75.
Neurodegener Dis. 2016 ; 16(3-4) : 161-171.

UNG DC, IACONO G, MEZIANE H, BLANCHARD E, PAPON MA, SELTEN M, VAN RHIJN JR, MONTJEAN R, RUCCI J, MARTIN S, FLEET A, BIRLING MC, MAROUILLAT S, ROEPMAN R, SELLOUM M, LUX A, THEPAULT RA, HAMEL P, MITTAL K, VINCENT JB, DORSEUIL O, STUNNENBERG HG, BILLUART P, NADIF KASRI N, HERAULT Y, LAUMONNIER F.
Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.
Mol Psychiatry. 2018 ; 23 : 1356-1367.

UMR INSERM U1259 : Morphogénèse et Antigénicité du VIH et du Virus des Hépatites (MAVIVH)

BOYER A, DUMANS A, BEAUMONT E, ETIENNE L, ROINGEARD P, MEUNIER JC.
The Association of Hepatitis C Virus Glycoproteins with Apolipoproteins E and B Early in Assembly Is Conserved in Lipoviral Particles.
J Biol Chem. 2014 ; 289(27) : 18904-18913.

TARTOUR K, APPOURCHAUX R, GAILLARD J, NGUYEN XN, DURAND S, TURPIN J, BEAUMONT E, ROCH E, BERGER G, MAHIEUX R, BRAND D, ROINGEARD P, CIMARELLI A.
IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Retrovirology. 2014 ; 11(1) : 103.

ETIENNE L, BLANCHARD E, BOYER A, DESVIGNES V, GAILLARD J, MEUNIER JC, ROINGEARD P, HOURIOUX C.
The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.
PLoS One. 2015 ; 4 : 10.

FOGERON ML, PAUL D, JIRASKO V, MONTSERRET R, LACABANNE D, MOLLE J, BADILLO A, BOUKADIDA C, GEORGEAULT S, ROINGEARD P, MARTIN A, BARTENSCHLAGER R, PENIN F, BÖCKMANN A.
Functional expression, purification, characterization, and membrane reconstitution of non-structural protein 2 from hepatitis C virus.
Protein Expr Purif. 2015 ; 116 : 1-6.

MONEL B, COMPTON AA, BRUEL T, AMRAOUI S, BURLAUD-GAILLARD J, ROY N, GUIVEL-BENHASSINE F, PORROT F, GENIN P, MEERTENS L, SINIGAGLIA L, JOUVENET N, WEIL R, CASARTELLI N, DEMANGEL C, SIMON-LORIERE E, MORIS A, ROINGEARD P, AMARA A, SCHWARTZ O.
Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.
EMBO J. 2017 ; 36(12):1653-1668.

PIVER E, BOYER A, GAILLARD J, BULL A, BEAUMONT E, ROINGEARD P, MEUNIER JC.
Ultrastructural organisation of HCV from the bloodstream of infected patients revealed by electron microscopy after specific immunocapture.
Gut. 2017, 66: 759-761.

MEYER L, LEYMARIE O, CHEVALIER C, ESNAULT E, MOROLDO M, DA COSTA B, GEORGEAULT S, ROINGEARD P, DELMAS B, QUERE P, LE GOFFIC R.
Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection.
PLoS One. 2017 ; 12(4):e0176355.

TARTOUR K, NGUYEN XN, APPOURCHAUX R, ASSIL S, BARATEAU V, BLOYET LM, BURLAUD-GAILLARD J, CONFORT MP, ESCUDERO-PEREZ B, GRUFFAT H, HONG SS, MOROSO M, REYNARD O, REYNARD S, DECEMBRE E, FTAICH N, ROSSI A, WU N, ARNAUD F, BAIZE S, DREUX M, GERLIER D, PARANHOS-BACCALA G, VOLCHKOV V, ROINGEARD P, CIMARELLI A.
Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs.
PLoS Pathog. 2017 ; 13(9) : e100661.

DEJARNAC O, HAFIRASSOU ML, CHAZAL M, VERSAPUECH M, GAILLARD J, PERERA-LECOIN M, UMANA-DIAZ C, BONNET-MADIN L, CARNEC X, TINEVEZ JY, DELAUGERRE C, SCHWARTZ O, ROINGEARD P, JOUVENET N, BERLIOZ-TORRENT C, MEERTENS L, AMARA A.
TIM-1 Ubiquitination Mediates Dengue Virus Entry.
Cell Rep. 2018 23(6) : 1779-1793.

PARIS J, TOBALY-TAPIERO J, GIRON M-L, BURLAUD-GAILLARD J, BUSEYNE F, ROINGEARD P, LESAGE P, ZAMBORLINI A, SAÏB A.
The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag.
Retrovirology 2018 ; 15 : 48.

FLODERER C, MASSON J-B, BOILLEY E, GEORGEAULT S, MERIDA P, EL BEHEIRY M, DAHAN M, ROINGEARD P, SIBATIRA J-B, FAVARD C, MURIAUX D.
Multiplexing single molecule localization and energy mapping reveal how the viral RNA coordinates HIV-1 Gag assembly in CD4 cells.
Sci Rep 2018, in press

UMR CNRS 7261 : Institut de Recherche sur la Biologie de l’Insecte (IRBI)

BEZIER A, THEZE J, GAVORY F, GAILLARD J, POULAIN J, DREZEN J, HERNIOU EA
The genome of the nucleopolyhedrosis causing virus from Tipula oleracea (ToNV) sheds new light into the Nudiviridae family.
J Virol. 2015 ; 89(6) : 3008-25

POIDATZ J, BRESSAC C, BONNARD O, THIERY D.
Delayed sexual maturity in males of Vespa velutina.
Insect Sci. 2018 ; 25 : 679-689.

UMR CNRS INRA 7247 : Physiologie de la Reproduction et des Comportements (PRC)

SANCHEZ-LAZO L, BRISARD D, ELIS S, MAILLARD V, UZBEKOV R, LABAS V, DESMARCHAIS A, PAPILLIER P, MONGET P, UZBEKOVA S.
Fatty acid synthesis and oxidation in cumulus cells support oocyte maturation in bovine.
Mol Endocrinol. 2014 ; 28(9) : 1502-1521.

LIVERA G, UZBEKOV R, JARRIER P, FOUCHECOURT S, DUQUENNE C, PARENT AS, MARINE JC, MONGET P.
Loss of oocytes due to conditional ablation of Murine double minute 2 (Mdm2) gene is p53-dependent and results in female sterility.
FEBS Lett. 2016 ; 590(16) : 2566-2574.

ALMIÑANA C, CORBIN E, TSIKIS G, ALCÂNTARA-NETO AS, LABAS V, REYNAUD K, GALIO L, UZBEKOV R, GARANINA AS, DRUART X, MERMILLOD P.
Oviduct extracellular vesicles protein content and their role during oviduct-embryo cross-talk.
Reproduction. 2017 ; 154(3) : 153-168.

LAMY J, CORBIN E, BLACHE MC, GARANINA AS, UZBEKOV R, MERMILLOD P, SAINT-DIZIER M.
Steroid hormones regulate sperm-oviduct interactions in the bovine.
Reproduction. 2017 ; 154(4) : 497-508.

ALMIÑANA C, TSIKIS G, LABAS V, UZBEKOV R, DA SILVEIRA JC, BAUERSACHS S, MERMILLOD P.
Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo.
BMC Genomics. 2018 ; 19(1) : 622.

ERL CNRS 7003 : Signalisation et Transports Ioniques Membranaires (STIM)

PASQUALIN C, GANNIER F, MALECOT C., BREDELOUX P, MAUPOIL V.
Automatic quantitative analysis of t-tubule organization in cardiac myocytes using ImageJ.
Am J Physiol Cell Physiol. 2015 ; 308 : C237-C245.

UMR INRA 1282 : Infectiologie et Santé Publique (ISP)

NICOL JT, LEBLOND V, ARNOLD F, GUERRA G, MAZZONI E, TOGNON M, COURSAGET P, TOUZE A.
Seroprevalence of human Malawi polyomavirus.
J Clin Microbiol. 2014 ; 52(1) : 321-323.

MARTEL-JANTIN C, FILIPPONE C, TORTEVOYE P, AFONSO PV, BETSEM E, DESCORPS-DECLERE S, NICOL JT, TOUZE A, COURSAGET P, CROUZAT M, BERTHET N, CASSAR O, GESSAIN A.
Molecular epidemiology of merkel cell polyomavirus: evidence for geographically related variant genotypes.
J Clin Microbiol. 2014 ; 52(5) : 1687-1690.

FLEURY MJ, TOUZE A, COURSAGET P.
Human papillomavirus type 16 pseudovirions with few point mutations in L1 major capsid protein FG loop could escape actual or future vaccination for potential use in gene therapy.
Mol Biotechnol. 2014 ; 56(5) : 479-486.

NICOL JT, LIAIS E, POTIER R, MAZZONI E, TOGNON M, COURSAGET P, TOUZE A.
Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses.
PLoS One. 2014 ; 9(5) : e97030.

MARTIN M, MOUGIN C, PRETET JL, GIL H, MEAUX-RUAULT N, PUZENAT E, RAMANAH R, AUBIN F, TOUZE A, COURSAGET P, JACQUIN E, MAGY-BERTRAND N.
Screening of human papillomavirus infection in women with systemic sclerosis.
Clin Exp Rheumatol.2014 ; 32(6 Suppl 86): S-145-148.

VIGUIER M, BACHELEZ H, POIRIER B, KAGAN J, BATTISTELLA M, AUBIN F, TOUZE A, CARMAGNAT M, FRANCES C, GOUGEON ML, FAZILLEAU N.
Peripheral and local humanpapillomavirus 16-specific CD8+ T-cell expansions characterize erosive oral
lichen planus.
J Invest Dermatol. 2015 ; 135(2) : 418-424.

COUTEAUDIER M, TRAPP-FRAGNET L, AUGER N, COURVOISIER K, PAIN B, DENESVRE C, VAUTHEROT JF.
Derivation of keratinocytes from chicken embryonic stem cells: Establishment and characterization of differentiated proliferative cell populations.
Stem Cell Res. 2015 ; 14(2) : 224-237.

FLEURY M, NICOL J, SAMIMI M, ARNOLD F, CAZAL R, BALLAIRE R, MERCEY O, GONNEVLLE H, COMBELAS N, VAUTHEROT J.F., MOREAU T, LORETTE G, COURSAGET P, TOUZET A.
Identification of the neutralizing epitopes of merkel cell polyomavirus major capsid protein within the BC and EF surface loops.
Plos One. 2015 ; e 10.1371.

DENESVRE C, RÉMY S, TRAPP-FRAGNET L, SMITH LP, GEORGEAULT S, VAUTHEROT JF, NAIR V.
Marek’s disease virus undergoes complete morphogenesis after reactivation in a T-lymphoblastoid cell line transformed by recombinant fluorescent marker virus.
J Gen Virol. 2016 ; 97(2) : 480-486.

COUTEAUDIER M, COURVOISIER K, TRAPP-FRAGNET L, DENESVRE C, VAUTHEROT JF.
Keratinocytes derived from chicken embryonic stem cells support Marek’s disease virus infection: a highly differentiated cell model to study viral replication and morphogenesis.
Virol J. 2016 ; 13:7.

TROTEREAU A, GONNET M, VIARDOT A, LALMANACH AC, GUABIRABA R, CHANTELOUP NK, SCHOULER C.
Complete Genome Sequences of Two Escherichia coli Phages, vB_EcoM_ ESCO5 and vB_EcoM_ESCO13, Which Are Related to phAPEC8.
Genome Announc. 2017 ; 5(13) : e01337-16.

VAUTHEROT JF, JEAN C, FRAGNET-TRAPP L, REMY S, CHABANNE-VAUTHEROT D, MONTILLET G, FUET A, DENESVRE C, PAIN B.
ESCDL-1, a new cell line derived from chicken embryonic stem cells, supports efficient replication of Mardiviruses.
PLoS One. 2017 ; e0175259.

ROCHE SM, HOLBERT S, TROTEREAU J, SCHAEFFER S, GEORGEAULT S, VIRLOGEUX-PAYANT I, VELGE P.
Salmonella Typhimurium Invalidated for the Three Currently Known Invasion Factors Keeps Its Ability to Invade Several Cell Models.
Front Cell Infect Microbiol. 2018 ; 10, 8: 273

EA 6295 : Nanomédicaments et nanosondes (NMNS)

GAUTIER J, ALLARD-VANNIER E, BURLAUD-GAILLARD J, DOMENECH J, CHOURPA I.
Efficacy and hemotoxicity of stealth doxorubicin-loaded magnetic nanovectors on breast cancer xenografts.
J. Biomed. Nanotechnol. 2014 ; 10 : 1-13.

CARROUÉE A, ALLARD-VANNIER E, MÊME S, SZEREMETA F, BELOEIL JC, CHOURPA I.
Sensitive trimodal magnetic resonance imaging-surface-enhanced resonance raman scattering-fluorescence detection of Cancer Cells with Stable Magneto-Plasmonic Nanoprobes.
Anal Chem. 2015 ; 87(22) : 11233-11241.

ALLARD-VANNIER É, HERVÉ-AUBERT K, KAAKI K, BLONDY T, SHEBANOVA A, SHAITAN KV, IGNATOVA AA, SABOUNGI ML, FEOFANOV AV, CHOURPA I.
Folic acid-capped PEGylated magnetic nanoparticles enter cancer cells mostly via clathrin-dependent endocytosis.
Biochim Biophys Acta – Gen Subj. 2017 ; 1861 : 1578-1586.

PERILLO E, HERVE-AUBERT K, ALLARD-VANNIER E, FALANGA A, GALDIERO S, CHOURPA I.
Synthesis and in vitro evaluation of fluorescent and magnetic nanoparticles functionalized with a cell penetrating peptide for cancer theranosis.
J Colloid Interface Sci. 2017 ; 499 : 209-217.

ALRIC C, HERVE-AUBERT K, AUBREY N, MELOUK S, LAJOIE L, MEME W, MEME S, COURBEBAISSE Y, IGNATOVA AA, FEOFANOV AV, CHOURPA I, ALLARD-VANNIER E.
Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes.
J Nanobiotechnology. 2018 ; 16:18.

HERVE-AUBERT K, ALLARD-VANNIER E, JOUBERT N, LAKHRIF Z, ALRIC C, MARTIN C, VIAUD-MASSUARD MC, DIMIER-POISSON I, AUBREY N, CHOURPA I.
Impact of site-specific sonjugation of ScFv to multifunctional nanomedicines using second generation maleimide.
Bioconjug Chem. 2018 ; 29 : 1553-1559.